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A multiscale mechanobiological modelling framework using agent-based models and finite element analysis: application

Houman Zahedmanesh¹, Caitríona Lally

¹School of Mechanical and Manufacturing Engineering, Dublin City University, Glasnevin, Dublin 9, Ireland.

Biomechanics and Modeling in Mechanobiology

|June 1, 2011

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This study presents a multiscale mechanobiological model for vascular tissue engineering. It shows that low scaffold compliance increases intimal hyperplasia, while pulsatile pressure reduces it, aiding graft design.

Area of Science:

Biomedical Engineering
Computational Biology
Mechanobiology

Background:

Vascular tissue engineering faces challenges in creating functional, long-term vascular grafts.
Computational models are crucial for understanding and predicting mechanobiological system behavior.

Purpose of the Study:

To present a novel multiscale mechanobiological modeling framework for vascular tissue engineering.
To investigate vascular smooth muscle cell (VSMC) growth dynamics in engineered scaffolds.

Main Methods:

Utilized a lattice-free agent-based model coupled with the finite element method.
Investigated the influence of scaffold compliance and loading conditions on VSMC growth.

Main Results:

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The model captured complex multiscale mechanobiological phenomena.

Low scaffold compliance promoted luminal ingrowth and intimal hyperplasia (IH).

Pulsatile pressure reduced luminal ingrowth and increased collagen synthesis compared to static conditions.

Conclusions:

The mechanobiological framework effectively models VSMC growth and IH development.
Scaffold properties and mechanical loading are critical for vascular graft design.
The model serves as a robust tool for hypothesis testing and design optimization in vascular tissue engineering.