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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Opioid analgesics in patients with chronic renal failure: principles for use and current guidelines]
Pasquale Niscola1, Marco Giovannini, Gisella Vischini
1Unita' Operativa di Ematologia, Ospedale S. Eugenio, Roma, Italy.
Abstract:
The treatment of pain in patients with impaired renal function may be problematic, especially when opioid drugs need to be used. In the presence of renal failure, significant changes occur in the metabolism and pharmacokinetics of these drugs, which can lead to adverse reactions due to the accumulation of parental compounds and active metabolites. This paper presents and discusses the available evidence concerning the optimal use of the most frequently employed opioid analgesics to treat pain in patients with renal impairment.
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