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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Jun 1, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

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Published on: December 13, 2017

Milestones in tremor research.

Rodger Elble1, Günther Deuschl

  • 1Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|June 1, 2011
PubMed
Summary
This summary is machine-generated.

Tremor is a common movement disorder with recent advances in understanding its causes and types. While deep brain stimulation is effective for severe cases, more research is needed for better treatments.

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Area of Science:

  • Neurology
  • Movement Disorders

Background:

  • Tremor is a frequent neurological condition encompassing diverse entities, as defined by the Movement Disorder Society.
  • Essential tremor and Parkinson tremor are the most prevalent and extensively researched forms.

Observation:

  • Significant advancements have been made in understanding tremor's clinical features, neuroimaging, epidemiology, and underlying pathophysiology.
  • Emerging research areas include tremor pathology and genetics, with newly identified tremor types like orthostatic, dystonic, cortical, and thalamic tremors.

Findings:

  • Research methodology for tremor treatment has improved, yet high-quality, double-blind controlled trials remain scarce.
  • Deep brain stimulation offers the most effective treatment for various tremors, typically for advanced stages.

Implications:

  • Continued research into tremor pathology and genetics may reveal novel therapeutic targets.
  • Further clinical trials are essential to validate and improve existing and new tremor treatments.
  • Expanding knowledge of diverse tremor types aids in accurate diagnosis and personalized patient care.