Related Experiment Video
Updated: Jun 1, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[The influence of sepsis as a complication after trauma on immune response to injury]
Introduction:
Mortality rate in trauma complicated with sepsis is exceeding 50%. Outcome is not determined only by infection or trauma, but also by the intensity of immuno-inflammatory response.
Objective:
The aim of this study was to determine the influence of sepsis on the immuno-inflammatory response, in the group of 35 traumatized men, of which in 25 cases trauma was complicated with sepsis.
Methods:
Cytokines were measured by ELISA test in plasma. Blood samples were drown on the first, third and fifth day after ICU admission.
Results:
Proinflammatory cytokine IL-8 was 230-fold higher in trauma + sepsis group (1148.48 vs. 5.05 pg/ml; p < 0.01), and antiinflammatory cytokine IL-ra was 4-fold higher (1138.3 vs. 310.05 pg/ml; p < 0.01), whereas IL-12 and IL-4 showed no significant difference between the groups.
Conclusion:
We concluded that sepsis, as a complication after trauma, drastically enhances immuno-inflammatory response to insult, as indicated by IL-8 and IL-ra, but not IL-12 and IL-4.
Related Concept Videos
Acute Inflammation III: Local and Systemic Effects
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Bacterial Meningitis II: Pathophysiology
Healing II: Complications
Inflammation
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

