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Updated: Jun 1, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
[Mechanism of general anesthesia and antinociception]
1Department of Anesthesia, Kyoto University Hospital, Kyoto 606-8507.
Abstract:
Nitrous oxide exhibits antinociceptive effects by inhibition of transmission of nociceptive information from the primary afferent neuron to the spinal cord neuron through the activation of the descending inhibitory pathway. Furthermore, nitrous oxide might directly modulate the nociceptive transmission at the dorsal horn of the spinal cord. Analysis of knockout mice and pharmacological analysis suggest that the K -opioid receptor and the nociceptin receptor are involved in the antinociceptive effects of nitrous oxide. To elucidate the molecular mechanism in pharmacological effects of nitrous oxide, further investigation is necessary.
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