Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026

Same author

Investigation of multilocus imprinting disturbance (MLID) in 101 Beckwith-Wiedemann spectrum patients.

Clinical epigenetics·2026

Same author

Single operator learning curve and insights into the adoption of transoral incisionless fundoplication 2.0 in the UK.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2025

Same author

<i>PIK3R1</i> and <i>G0S2</i> are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation.

Epigenetics·2025

Same author

Non-canonical imprinting, manifesting as post-fertilization placenta-specific parent-of-origin dependent methylation, is not conserved in humans.

Human molecular genetics·2025

Same author

Multi-locus imprinting disturbance (MLID): interim joint statement for clinical and molecular diagnosis.

Clinical epigenetics·2024

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Does genomic imprinting play a role in autoimmunity?

Cristina Camprubí¹, David Monk

¹Imprinting and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Institute ofBiomedical Investigation, Barcelona, Spain.

Advances in Experimental Medicine and Biology

|June 2, 2011

Summary

Genomic imprinting, an exception to Mendelian inheritance, involves parent-specific gene expression. This chapter explores its role in autoimmunity, focusing on how imprinted microRNAs may affect autoimmune disease-associated genes.

More Related Videos

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Related Experiment Videos

Last Updated: Jun 1, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Area of Science:

Genetics and Molecular Biology
Immunology
Epigenetics

Background:

Gregor Mendel's laws of genetic inheritance established the principle of gene equivalence regardless of parental origin.
Exceptions to Mendelian inheritance include sex-linked traits, mitochondrial genes, and genomic imprinting.
Genomic imprinting results in monoallelic expression, where only the maternal or paternal allele is transcribed.

Purpose of the Study:

To discuss the role of parent-of-origin effects and genomic imprinting in autoimmune diseases.
To explore the potential influence of imprinted microRNAs (miRNAs) on autoimmune-associated genes.

Main Methods:

Review and discussion of existing literature on genomic imprinting and autoimmunity.
Speculative analysis of imprinted miRNA mechanisms in autoimmune gene regulation.

Main Results:

Genomic imprinting represents a significant deviation from classical Mendelian inheritance in mammals.
Parent-of-origin effects, including imprinting, are implicated in the pathogenesis of autoimmune disorders.

Conclusions:

Genomic imprinting is a crucial epigenetic mechanism with potential implications for autoimmune diseases.
Imprinted miRNAs may serve as key regulators influencing the expression of multiple genes associated with autoimmunity.