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Updated: Jun 1, 2026
06:15
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Bevacizumab-induced hypertension: pathogenesis and management
Kostas N Syrigos1, Eleni Karapanagiotou, Paraskevi Boura
1Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Athens Medical School, Greece.
Summary
Bevacizumab, an anti-VEGF therapy, can cause hypertension. Home blood pressure monitoring is crucial for managing this side effect, with current guidelines recommending general hypertension treatment approaches.
Area of Science:
- Oncology
- Pharmacology
- Nephrology
Background:
- Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor (VEGF).
- It is approved for various cancers, including colorectal, lung, renal cell carcinoma, and glioblastoma.
- Anti-VEGF therapy, including bevacizumab, is associated with significant toxicities, notably hypertension.
Purpose of the Study:
- To review the incidence, pathophysiology, and management of bevacizumab-induced hypertension.
- To highlight the importance of blood pressure monitoring in patients receiving bevacizumab.
- To discuss current approaches and the need for specific guidelines for managing this adverse event.
Main Methods:
- Literature review of studies on bevacizumab and hypertension.
- Analysis of proposed pathophysiological mechanisms (nitric oxide, renal impairment, pre-eclampsia-like).
- Evaluation of current monitoring and management strategies.
Main Results:
- Hypertension incidence varies among malignancies and may be dose-dependent.
- Home blood pressure monitoring is recommended for accurate assessment.
- No specific antihypertensive recommendations exist; general guidelines are advised.
Conclusions:
- Bevacizumab-induced hypertension requires careful monitoring and management.
- Further randomized studies are needed to establish specific treatment guidelines.
- Current management relies on general hypertension protocols while awaiting evidence-based recommendations.
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