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High p16 expression predicts a positive response to chemoradiotherapy in stage IVa/b head and neck squamous cell
Yi-Ju Chen1, Kun-Ming Rau, Chih-Yen Chien
1Department of Pathology,Cancer Center, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan. taijanchiu@163.com
Background:
The objective of this study was to evaluate the effect of p16 expression on response to chemoradiation in stage IVa/b head and neck squamous cell carcinoma (HNSCC) patients.
Methods:
We retrospectively identified 64 patients with stage IVa/b HNSCC who received chemoradiation. Eligibility criteria included presence of biopsy-proven stage IVa/b HNSCC without a prior history of chemotherapy or radiotherapy. Immunohistochemistry was used to assess p16 protein expression in pretreatment biopsy specimens.
Results:
Of the 64 patients, 38 showed high p16 expression, and 50 patients responded to chemoradiotherapy, 32 exhibiting a complete and 18 a partial response. Response was significantly associated with p16 expression (P < 0.001) and multivariate analysis indicated that that p16 expression (HR: 2.62, 95%C.I.: 1.14-6.06; P=0.024) was an independent prognostic factor for overall survival.
Conclusions:
High p16 expression predicts a better response to chemoradiation in patients with stage IVa/b HNSCC.
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