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The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion
Nina Pereza1, Saša Ostojić, Marija Volk
1Department of Biology and Medical Genetics, University of Rijeka, Rijeka, Croatia. nina.pereza@xnet.hr
Objective:
The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA).
Methods:
Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples.
Results:
There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls.
Conclusions:
We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.
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