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Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Neil J Glassford1, K J Farley, Stephen Warrillow

  • 1Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.

Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine
|June 2, 2011
PubMed

This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 µmol/L. After liver transplantation, ammonia uptake decreased to 0 µmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.

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