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Updated: Jun 1, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

TRP channels in cell survival and cell death in normal and transformed cells

George Shapovalov1, V'yacheslav Lehen'kyi, Roman Skryma

  • 1INSERM U1003, Equipe Labellisee par la Ligue Nationale Contre le Cancer, Universite de Sciences et Technologies de Lille (USTL), F-59655 Villeneuve d'Ascq, France. george.shapovalov@inserm.fr

Cell Calcium
|June 2, 2011
PubMed

Insights

Transient Receptor Potential (TRP) channels regulate cell fate by controlling calcium (Ca2+) levels. Their localization and function are crucial for maintaining cell survival or triggering apoptosis, with dysregulation linked to cancer development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Transient Receptor Potential (TRP) channels are a diverse protein superfamily involved in cellular signaling.
  • These channels play a critical role in regulating calcium (Ca2+) homeostasis.
  • TRP channels influence key cellular processes, including cell fate determination.

Purpose of the Study:

  • To review the role of TRP channel localization and function in regulating cell survival and death.
  • To explore how TRP channel dysregulation contributes to cancer pathogenesis.
  • To highlight the connection between Ca2+ signaling via TRP channels and cell fate decisions.

Main Methods:

  • Literature review of studies on TRP channel localization and function.
  • Analysis of evidence linking TRP channels to Ca2+ homeostasis and cell fate.
  • Examination of research on TRP channel dysregulation in cancer.

Main Results:

  • TRP channels' colocalization with Ca2+-sensing elements dictates cell fate outcomes (proliferation vs. apoptosis).
  • Specific TRP channel activity determines the effect of Ca2+ entry on cell survival.
  • Aberrant TRP channel function perturbs the balance between cell survival and death.

Conclusions:

  • TRP channels are key regulators of the cell survival-death balance.
  • Disruptions in TRP channel activity and localization are implicated in cancer development.
  • Understanding TRP channel mechanisms offers potential therapeutic targets for cancer treatment.

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