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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Quantifying lung shunting during planning for radio-embolization.

Kathy Willowson¹, Dale L Bailey, Clive Baldock

¹Institute of Medical Physics, School of Physics, University of Sydney, Camperdown, NSW 2006, Australia. K.Willowson@physics.usyd.edu.au

Physics in Medicine and Biology

|June 2, 2011

Summary

A new method accurately quantifies lung uptake in liver cancer patients during radio-embolization. This technique improves upon subjective analyses of technetium-99m macroaggregated albumin ([(99m)Tc]-MAA) shunt studies, offering precise lung shunt quantification.

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Area of Science:

Nuclear Medicine
Radiology
Oncology

Background:

Current analysis of [(99m)Tc]-MAA shunt studies for liver cancer radio-embolization is subjective and variable.
Accurate quantification of lung shunt is crucial for treatment planning and dose estimation.

Purpose of the Study:

To propose and validate a simple, accurate method for quantifying lung uptake during [(99m)Tc]-MAA shunt studies.
To enable precise estimation of absorbed radiation dose to lung tissue.

Main Methods:

A novel technique involving a peripheral intravenous injection of macroaggregated albumin (MAA) with two static acquisitions.
Quantitative analysis of lung activity to determine arterio-venous shunting.
Comparison with a gold standard quantitative SPECT/CT imaging technique.

Main Results:

The proposed method demonstrated high accuracy, with an average difference of 2% (range 1-8%) compared to the gold standard.
The technique provides simple and fast quantification of lung shunting.
Accurate estimates of absorbed dose to lung tissue were achievable.

Conclusions:

The proposed method offers a simple, fast, and accurate approach for quantifying lung shunting in radio-embolization patients.
This technique facilitates reliable estimation of absorbed lung dose, improving treatment planning.
Potential for integration into a single procedure for planning and therapy.