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[Joint morphogenesis and development of permanent articular cartilage]
Yoichi Ohta1, Masahiro Iwamoto
1Department of Surgery, The Children's Hospital of Philadelphia Research Institute, PA, USA.
Clinical Calcium
|June 2, 2011
Summary
This review details limb skeletal development, focusing on how progenitor cells form cartilage and synovial joints. It highlights key factors in joint morphogenesis and potential treatments for joint diseases.
Area of Science:
- Developmental biology
- Cell biology
- Biochemistry
Context:
- Limb skeletogenesis involves progenitor mesenchymal cell aggregation to form precartilaginous condensations.
- These condensations undergo chondrogenesis, forming cartilaginous anlagen with incipient synovial joints.
- Joint formation, organization, and morphogenesis are regulated by numerous factors.
Purpose:
- To review recent advances in synovial joint morphogenesis.
- To summarize the actions of key molecular players in joint and articular cartilage formation.
- To discuss the translation of basic research findings toward treating joint diseases.
Summary:
- Progenitor mesenchymal cells aggregate during limb skeletogenesis, forming condensations that develop into cartilaginous structures.
- These structures exhibit synovial joints at their ends, with complex regulatory mechanisms governing their development.
- The review covers key factors influencing joint and cartilage formation and discusses therapeutic applications.
Impact:
- Provides a comprehensive overview of joint morphogenesis and articular cartilage development.
- Identifies key molecular players and regulatory mechanisms in skeletal development.
- Suggests potential research directions for treating joint diseases and improving cartilage regeneration.
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The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
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During development, the limbs...
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01:16Structural Joints: Synovial Joints
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