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New triterpenes from Barringtonia asiatica.

Consolacion Yasaña Ragasa1, Dinah Lorenzana Espineli, Chien-Chang Shen

  • 1Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, Manila, Philippines. consolacion.ragasa@dlsu.edu.ph

Chemical & Pharmaceutical Bulletin
|June 2, 2011
PubMed
Summary

Two new triterpenes from Barringtonia asiatica leaves, germanicol caffeoyl ester and camelliagenone, were identified. These compounds, along with others, demonstrated significant antifungal and antibacterial activities.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Barringtonia asiatica is a plant species known for its traditional medicinal uses.
  • The chemical constituents of Barringtonia asiatica, particularly from its leaves, fruits, and seeds, are of interest for potential therapeutic applications.

Purpose of the Study:

  • To isolate and characterize new chemical compounds from the leaves of Barringtonia asiatica.
  • To evaluate the antifungal and antibacterial activities of the isolated compounds.

Main Methods:

  • Extraction and isolation of compounds from Barringtonia asiatica leaves, fruits, and seeds.
  • Structure elucidation using extensive 1D- and 2D-NMR spectroscopy.
  • Antimicrobial susceptibility testing against Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa.

Main Results:

  • Two new triterpenes, germanicol caffeoyl ester (1) and camelliagenone (2), were identified from the leaves.
  • Several known compounds including germanicol trans-coumaroyl ester (3), germanicol cis-coumaroyl ester (4), germanicol (5), camelliagenin A (6), spinasterol, sitosterol, squalene, lutein, and trilinolein were also isolated.
  • Compounds 1-5 showed antifungal activity against Candida albicans.
  • Compounds 1-3 and 5 exhibited antibacterial activity against Staphylococcus aureus.
  • Compound 5 demonstrated activity against Pseudomonas aeruginosa.

Conclusions:

  • The leaves of Barringtonia asiatica are a source of novel triterpenes with potential medicinal properties.
  • The isolated compounds possess significant antifungal and antibacterial activities, warranting further investigation for drug development.