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Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury

Gi-Wook Hwang1, Jin-Yong Lee, Katsunori Ryoke

  • 1Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohoku University, Sendai, Miyagi 980-8578, Japan.

The Journal of Toxicological Sciences
|June 2, 2011
PubMed

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...