Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Drug Toxicity: Risk factors

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

Drug toxicity: Idiosyncratic Reactions

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effectiveness of e-learning material on essential components of evidence-based medicine among laypersons: a randomized controlled trial.

Health education research·2024

Same author

E-Learning Material of Evidence-Based Medicine for Laypersons.

Health literacy research and practice·2022

Same author

Healthcare use and RT-PCR testing during the first wave of the COVID-19 pandemic in Japan.

Journal of general and family medicine·2022

Same author

Health-care-seeking behaviours of the Japanese lay public during the COVID-19 pandemic: a cross-sectional study.

Journal of primary health care·2021

Same author

Updates to and quality of clinical practice guidelines for high-priority diseases in Japan.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2019

Same author

["Choosing Wisely" Improves Shared Decision Making].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2019

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Drug safety--from patients' perspective].

Kyoko Kitazawa¹

¹Nikkei Business Publications, Inc., Tokyo, Japan. kitazawa@nikkeibp.co.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan

|June 2, 2011

Summary

Most drugs are not 100% effective or safe. Enhancing drug development, improving medication safety, refining drug information, and advancing personalized medicine are crucial for better patient outcomes.

Area of Science:

Pharmaceutical Sciences
Health Services Research
Medical Ethics

Context:

Patient expectations for drug efficacy and safety often exceed current realities.
Most available drugs do not achieve 100% effectiveness or safety.
Continuous improvement in pharmaceutical development and delivery is essential.

Purpose:

To identify key challenges in drug therapy from a layperson's perspective.
To highlight areas for improvement in the pharmaceutical lifecycle.
To advocate for enhanced drug development and patient-centered communication.

Summary:

Challenges include developing drugs for neglected diseases, preventing medication errors through clear communication, improving the quality of drug information dissemination, and promoting personalized medicine via pharmacogenomics and PK/PD research.

More Related Videos

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Published on: March 11, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Published on: March 11, 2017

Addressing these challenges requires a multi-faceted approach involving healthcare professionals, industry, and patients.

Focusing on unmet medical needs and individual patient variability is key.

Impact:

Potential to improve overall drug efficacy and patient safety.
Reduction in medication errors and enhanced patient understanding of treatments.
Advancement towards tailored pharmaceutical interventions and better public health outcomes.