Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are themselves.
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistent Negative Symptoms: Characterization of an Unmet Need in a Learning Health System for First-Episode Psychosis.

Schizophrenia bulletin·2026
Same author

Efficacy, Acceptability, and Feasibility of StayQuit for Sustaining Smoking Abstinence After Psychiatric Hospitalization: A Pilot Study.

Journal of patient-centered research and reviews·2026
Same author

Bridging the Hospital Discharge Gap: Pilot Trial of a Digital Smoking Cessation Program for Psychiatric Inpatients.

Psychiatric services (Washington, D.C.)·2026
Same author

The association between psychotropic medications and cognitive functioning in bipolar disorder.

International journal of bipolar disorders·2026
Same author

Risk Factors for Natural Cause Mortality in Bipolar Disorder.

Bipolar disorders·2026
Same author

Levels of matrix metalloproteinase 9 (MMP-9) are elevated in persons with major depressive disorder who have had a recent suicide attempt.

Brain, behavior, & immunity - health·2026

Related Experiment Video

Updated: Jun 1, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Cognitive functioning in recent onset psychosis.

Faith Dickerson1, Cassie Stallings, Crystal Vaughan

  • 1Sheppard Pratt, Baltimore, MD 21204, USA. fdickerson@sheppardpratt.org

The Journal of Nervous and Mental Disease
|June 2, 2011
PubMed
Summary
This summary is machine-generated.

Cognitive functioning is impaired in recent onset psychosis for both schizophrenia-spectrum and bipolar disorder patients. Bipolar disorder patients showed better cognitive performance than schizophrenia-spectrum patients.

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Related Experiment Videos

Last Updated: Jun 1, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Recent onset psychosis is associated with significant cognitive deficits.
  • Understanding the specific cognitive profiles in early psychosis is crucial for diagnosis and treatment.

Purpose of the Study:

  • To compare cognitive functioning in individuals with recent onset psychosis (schizophrenia-spectrum disorders vs. bipolar disorder) and nonpsychiatric controls.
  • To identify specific cognitive domains affected in early psychosis.

Main Methods:

  • Utilized the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Wisconsin Card Sorting Test (WCST).
  • Compared cognitive performance across three groups: schizophrenia-spectrum disorder (n=56), bipolar disorder (n=60), and nonpsychiatric controls (n=312).
  • Employed analysis of covariance to compare cognitive variables among groups.

Main Results:

  • Significant differences in cognitive variables were observed among all three groups.
  • Individuals with recent onset psychosis demonstrated broadly impaired cognitive performance compared to controls.
  • Bipolar disorder patients exhibited a cognitive advantage over schizophrenia-spectrum patients on RBANS Language, Total score, and marginally on Immediate Memory.

Conclusions:

  • Recent onset psychosis is characterized by widespread cognitive impairment.
  • Bipolar disorder patients with recent onset psychosis may have a more favorable cognitive profile compared to those with schizophrenia-spectrum disorders.
  • Cognitive assessment tools like RBANS and WCST are valuable in differentiating cognitive deficits in early psychosis.