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Updated: Jun 1, 2026
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Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
Published on: November 4, 2015
Influenza virus and cell signaling pathways
Pratibha Gaur1, Ashok Munjhal, Sunil K Lal
1Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi, India.
Summary
Influenza A virus causes widespread illness and death by hijacking host cell signaling pathways. This review details how viral infections impact key pathways like NF-κB and MAPK signaling.
Area of Science:
- Virology
- Cell Biology
- Immunology
Background:
- Influenza viruses are significant global respiratory pathogens causing morbidity and mortality.
- Influenza A virus, with its segmented RNA genome, rapidly mutates, leading to variant formation.
- Viral proteins interact with host proteins, exploiting cellular pathways for replication.
Purpose of the Study:
- To provide a research update on influenza virus infection.
- To discuss the impact of influenza viral infection on host cell signaling pathways.
Main Methods:
- This is a review article, synthesizing existing research.
- It focuses on the interplay between viral proteins and host intracellular signaling cascades.
- Specific pathways examined include NF-κB, PI3K/Akt, MAPK, PKC/PKR, and TLR/RIG-I.
Main Results:
- Influenza virus inhibits host protein synthesis while promoting viral protein expression.
- Viral infection hijacks multiple intracellular signaling cascades for viral transcription and replication.
- The review details the specific mechanisms by which influenza impacts these pathways.
Conclusions:
- Understanding influenza's manipulation of cell signaling is crucial for combating viral pathogenesis.
- This knowledge can inform the development of new antiviral strategies.
- Further research into these host-pathogen interactions is warranted.
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