Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteinuria and gall bladder wall thickness as predictive indicators for dengue severity in pediatric patients.

Paediatrics & child health·2026
Same author

Evaluation of ChatGPT's Accuracy, Repeatability, and Reasoning Ability in Prosthodontics Education: A Cross-Sectional Comparative Study with Prosthodontists.

Journal of clinical and experimental dentistry·2026
Same author

A Novel Denture Teeth Arrangement Jig with Three-dimensional Printed Tooth Positioning Blocks.

Contemporary clinical dentistry·2025
Same author

Clinicodemographic and Biochemical Profile of Children with Dengue Infection.

Indian journal of pediatrics·2025
Same author

Parental Knowledge and Perceptions of the First Episode of Seizure in Children: A Single-Center Cross-Sectional Study.

Sage open pediatrics·2025
Same author

Adrenal Insufficiency after Steroid Therapy in Children with Steroid-Sensitive Nephrotic Syndrome: A Cross-sectional Study.

Indian journal of endocrinology and metabolism·2025

Related Experiment Video

Updated: Jun 1, 2026

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore
09:15

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

Megaloblastic anemia--a rare cause.

Sanjib Kr Debnath1, Anju Aggarwal, Hema Mittal

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi, India.

Indian Journal of Pediatrics
|June 2, 2011
PubMed
Summary

A rare cause of megaloblastic anemia was identified in a young boy with developmental issues. Increased urinary orotic acid excretion, not typical metabolic errors, explained the condition.

Area of Science:

  • Biochemistry
  • Pediatric Hematology
  • Clinical Genetics

Background:

  • Megaloblastic anemia in young children can stem from various causes, including vitamin deficiencies.
  • Normal vitamin B12, folic acid, and iron levels necessitate exploring alternative etiologies.

Observation:

  • A 2-year-old boy exhibited unresponsive megaloblastic anemia, growth failure, and developmental delay.
  • Standard metabolic screening via tandem mass spectroscopy yielded normal results.
  • Elevated urinary orotic acid excretion was detected.

Findings:

  • The patient's presentation was attributed to a rare metabolic disorder characterized by increased urinary orotic acid.
  • This finding suggests orotic aciduria as a potential, albeit uncommon, cause of megaloblastic anemia in pediatric cases.

More Related Videos

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Related Experiment Videos

Last Updated: Jun 1, 2026

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore
09:15

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Implications:

  • Highlights the importance of considering orotic aciduria in the differential diagnosis of unexplained megaloblastic anemia in children.
  • Underscores the utility of urinary orotic acid analysis when common causes are ruled out.
  • Contributes to the understanding of rare metabolic disorders affecting hematopoiesis and development.