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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

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Related Experiment Video

Updated: Jun 1, 2026

Xenopus laevis Egg Extract Preparation and Live Imaging Methods for Visualizing Dynamic Cytoplasmic Organization
05:58

Xenopus laevis Egg Extract Preparation and Live Imaging Methods for Visualizing Dynamic Cytoplasmic Organization

Published on: June 6, 2021

Regulatory pathways coordinating cell cycle progression in early Xenopus development.

Tetsuya Gotoh1, Linda M Villa, Daniel G S Capelluto

  • 1Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA 24061, USA.

Results and Problems in Cell Differentiation
|June 2, 2011
PubMed
Summary
This summary is machine-generated.

The African clawed frog (Xenopus laevis) is a key model for cell cycle regulation research. Its simple early cell cycle aids in understanding fundamental cell division and gene expression mechanisms.

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Last Updated: Jun 1, 2026

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Understanding Early Organogenesis Using a Simplified In Situ Hybridization Protocol in Xenopus
14:50

Understanding Early Organogenesis Using a Simplified In Situ Hybridization Protocol in Xenopus

Published on: January 12, 2015

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • The African clawed frog (Xenopus laevis) serves as a vital model organism in biological research.
  • It has been instrumental in understanding cell development and cell cycle regulation for over two decades.

Purpose of the Study:

  • To investigate the fundamental mechanisms governing cell cycle transitions in Xenopus laevis.
  • To explore the roles of cellular components, signaling pathways, and gene expression in cell cycle regulation.
  • To analyze the simplicity of the Xenopus early cell cycle for dissecting key regulatory components.

Main Methods:

  • Studying the differential expression of cyclin/Cdk complexes during early cell cycles.
  • Analyzing the interplay of cyclin synthesis and degradation in cell cycle progression.
  • Investigating the selection of specific substrates by Cdk components.

Main Results:

  • Early cell divisions in Xenopus are rapid, alternating DNA synthesis and division phases.
  • Post-blastula stages introduce gap phases, allowing for DNA repair.
  • Differential expression of cyclin/Cdk complexes drives orderly cell cycle progression.

Conclusions:

  • The Xenopus early cell cycle's simplicity facilitates the dissection of fundamental cell cycle components.
  • Cell proliferation and differentiation are coordinated during early embryogenesis through cell cycle control gene signaling.
  • Understanding Xenopus cell cycle mechanisms provides insights into broader principles of multicellular development.