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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

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Updated: Jun 1, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Drug shortage turns severe.

Howard Larkin

    Trustee : the Journal for Hospital Governing Boards
    |June 3, 2011
    PubMed
    Summary

    Limited production capacity and raw material shortages are causing medication supply chain disruptions. Facilities must proactively implement strategies to prevent critical drug shortages and ensure patient care continuity.

    Area of Science:

    • Pharmaceutical sciences
    • Healthcare management
    • Supply chain logistics

    Background:

    • Current pharmaceutical manufacturing faces significant challenges impacting drug availability.
    • Global supply chain vulnerabilities, including raw material sourcing and production limitations, are increasing medication shortages.
    • Ensuring consistent access to essential medicines is critical for patient health outcomes and healthcare system stability.

    Purpose of the Study:

    • To identify and analyze the primary drivers of current medication shortages.
    • To propose actionable strategies for healthcare facilities to mitigate the impact of limited production capacity and raw material concerns.
    • To provide a framework for enhancing pharmaceutical supply chain resilience.

    Main Methods:

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    Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
    16:31

    Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

    Published on: June 6, 2011

    Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine
    09:37

    Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine

    Published on: August 24, 2018

  • Review of current literature on pharmaceutical supply chain management and drug shortages.
  • Analysis of case studies detailing facility-level responses to medication scarcity.
  • Development of a risk assessment model for identifying potential supply chain vulnerabilities.
  • Main Results:

    • Key factors contributing to shortages include single-source raw material dependency, geopolitical instability, and manufacturing process complexities.
    • Proactive inventory management, diversification of suppliers, and strategic partnerships are effective mitigation tactics.
    • Enhanced communication and data sharing among stakeholders can improve early detection of potential shortages.

    Conclusions:

    • Healthcare facilities must adopt a proactive, multi-faceted approach to manage medication supply risks.
    • Diversifying supply sources and building robust inventory systems are essential for maintaining drug availability.
    • Continuous monitoring and adaptive strategies are necessary to navigate the evolving landscape of pharmaceutical production and raw material sourcing.