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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

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Published on: August 26, 2017

Microscopic polyangiitis involving the breast.

M Devinck¹, B Vander Cruyssen, K Lambein

¹Department of Rheumatology, University Hospital Gent, Belgium. mieke.devinck@telenet.be

Acta Clinica Belgica

|June 3, 2011

Summary

This summary is machine-generated.

Microscopic polyangiitis, a rare autoimmune condition, can manifest with breast lesions alongside systemic symptoms. Early autoimmune serology is crucial for diagnosis, especially before considering surgery for breast abnormalities.

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Area of Science:

Rheumatology
Internal Medicine
Oncology

Background:

Autoimmune diseases, particularly anti-Neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis, can present with diverse systemic manifestations.
Breast lesions are typically evaluated for malignancy, but rare inflammatory or autoimmune conditions should also be considered.

Observation:

A 76-year-old woman presented with constitutional symptoms including dry cough, low-grade fever, arthralgia, myalgia, and weight loss.
Radiographic imaging revealed bilateral lung nodules and a suspicious breast lesion, alongside impaired renal function with proteinuria.

Findings:

The patient was diagnosed with microscopic polyangiitis involving the breast, confirmed by clinical, radiographic, serological (positive auto-immune), and histological findings.
This diagnosis highlights the importance of considering ANCA-associated vasculitis in patients with breast lesions and systemic symptoms.

Implications:

Breast involvement in vasculitis is uncommon but should be suspected in patients with unexplained constitutional symptoms and breast abnormalities.
Autoimmune serology testing is recommended for patients with breast lesions and systemic symptoms to guide diagnosis and treatment, potentially avoiding unnecessary surgery.