Inositol monophosphate esterase inhibition by lithium in normal human studies using neuroendocrine tests. Part II....

1. Recent preclinical researches gave evidence that the actions of many neurotransmitters and drugs are mediated through the activation of the turnover of phosphatidylinositol 4,5 biphosphate (PIP2). Lithium (Li) a specific inhibitor of the enzyme inositol monophosphate esterase reduces the turn over of PIP2 and decreases the cell responses mediated via the cleavage of PIP2. 2. The authors studied the influence of a therapeutic single dose of Li on the response of human growth hormone (HGH) prolactin (PRL) and thyrotropin (TSH) to clonidine (C), an alpha adrenergic agonist which stimulates the turn over of PIP2. 3. Li reduces the HGH response to C in 3, increases in 1 and provokes no change in 2 subjects. The basal secretion of PRL and TSH were not modified. 4. These findings could support the hypothesis that some of the action of Li in humans is mediated through the inhibition of the enzyme inositol monophosphate esterase. Further studies are needed in order to determine the importance of this action.