Blue nevus of the prostate

Area of Science:

• Uropathology
• Dermatopathology
• Oncology

Background:

• Melanotic lesions, such as blue nevus, can incidentally occur in the prostate.
• Blue nevus is the most frequently identified melanocytic lesion within the prostate gland.

Purpose of the Study:

• To review the literature on blue nevus of the prostate.
• To differentiate blue nevus from other prostate lesions, including melanosis, malignant melanoma, and nonmelanotic conditions.

Main Methods:

• Comprehensive literature review of reported cases of blue nevus in the prostate.
• Analysis of histomorphologic features.
• Evaluation of histochemical and immunohistochemical staining.

Main Results:

• Identified 28 previously reported cases of blue nevus in the prostate.
• Blue nevus is the most common melanocytic lesion in the prostate.
• Differential diagnosis includes melanosis, malignant melanoma, lipofuscin, hemosiderin, and homogentisic acid deposition.
• Histomorphology and special stains (iron, S100 protein, HMB-45, CD68) aid in diagnosis.

Conclusions:

• Blue nevus of the prostate is a benign lesion.
• It has no documented malignant potential.
• No further treatment is necessary for blue nevus of the prostate.