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[Cerebral computed tomography in infantile spasms].

H Pedersen1, K Neergaard, P Howitz

  • 1Rigshospitalet, neuroradiologisk afsnit, København.

Ugeskrift for Laeger
|May 28, 1990
PubMed
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Computed tomography (CT) revealed abnormalities in 60% of infantile spasms cases. However, CT findings did not correlate with psychomotor development, suggesting early treatment is key for idiopathic infantile spasms.

Area of Science:

  • Pediatric Neurology
  • Neuroradiology
  • Developmental Neuroscience

Background:

  • Infantile spasms are a severe epilepsy syndrome in infants.
  • Early diagnosis and treatment are crucial for optimal neurodevelopmental outcomes.
  • The role of neuroimaging in classifying infantile spasms remains important.

Purpose of the Study:

  • To investigate the utility of computed tomography (CT) in evaluating children with infantile spasms.
  • To correlate CT findings with psychomotor development in infantile spasms.
  • To differentiate between symptomatic and idiopathic infantile spasms using CT.

Main Methods:

  • A prospective study involving 52 children diagnosed with infantile spasms.
  • All participants underwent computed tomography (CT) brain imaging.

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  • Psychomotor development was assessed in relation to CT findings.

    • Main Results:

    • Computed tomography (CT) showed normal findings in 40% of cases.
    • Pathological CT findings included ventricular/subarachnoid space dilatation (17%), congenital malformations (19%), and cerebrovascular changes (19%).
    • No significant difference in psychomotor development was observed between children with normal and abnormal CT scans.

    Conclusions:

    • Computed tomography (CT) is valuable for differentiating symptomatic from idiopathic infantile spasms.
    • Early initiation of ACTH treatment may lead to a good prognosis in idiopathic cases, irrespective of CT findings.
    • Subtle malformations like neuronal heterotopia may be missed by CT, with MRI potentially offering better visualization.