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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Development and characterization of rifampicin loaded floating microspheres
Pankaj Goyal1, S Gill, U D Gupta
1Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, Moga (Punjab), India.
Summary
This study developed rifampicin floating microspheres for sustained drug delivery. These microspheres demonstrated prolonged release and increased gastric retention time, enhancing anti-tubercular treatment potential.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biopharmaceutics
Background:
- Gastroretentive floating microspheres offer enhanced bioavailability and controlled drug release.
- Increasing gastric retention time is crucial for optimizing drug efficacy.
Purpose of the Study:
- To develop rifampicin-loaded floating microspheres.
- To enhance the gastric retention time of rifampicin for improved therapeutic outcomes.
Main Methods:
- Microspheres were prepared using the solvent evaporation technique.
- Characterization included particle size, shape, zeta-potential, entrapment efficiency, and release kinetics.
- Buoyancy was assessed over an 8-hour period.
Main Results:
- The developed microspheres were predominantly spherical.
- Entrapment efficiency reached 86.34%.
- Percentage buoyancy after 8 hours was 61.06%, indicating good gastric retention.
Conclusions:
- Rifampicin floating microspheres exhibit prolonged drug release in a gastric medium.
- These systems hold potential for sustained delivery of anti-tubercular drugs.
- The developed microspheres can improve therapeutic efficacy through enhanced gastric residence time.
