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Published on: July 10, 2014
Preparation and characterization of bioadhesive systems containing propolis or sildenafil for dental pulp protection
Franciele Viana Fabri1, Rogério Rodrigues Cupertino, Mirian Marubayashi Hidalgo
1Department of Pharmacy, State University of Maringa, Maringa, Parana, Brazil.
Purpose:
Binary polymeric systems containing poloxamer 407 (P407) and Carbopol 934P (C934P) were designed to deliver propolis extract (PE) or sildenafil citrate for the endodontic treatment (pulp protection).
Methods:
Gelation temperature, rheology (flow), bioadhesion, and in vitro drug release of formulations were determined.
Results:
Formulations showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 34-37°C. In addition, they exhibited pseudoplastic flow and low degrees of thixotropy or rheopexy. The greatest bioadhesion was noted in the formulation containing 20% P407 (w/w) and 0.10% C934P (w/w). PE release from formulation containing 15% P407 (w/w) and 0.25% C934P (w/w) was controlled by the phenomenon of relaxation of polymer chains. Moreover, sildenafil release from formulation containing 20% P407 (w/w) and 0.10% C934P (w/w) was controlled by Fickian diffusion.
Conclusion:
The data obtained on these formulations indicate a potentially useful role in the endodontic treatment (pulp protection) and suggest they are worthy of clinical evaluation.
