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Updated: Jun 1, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Targeting interleukin-1β for pain
1Kareus Therapeutics, Norcross, GA 30071, USA. perlecan@gmail.com
Abstract:
Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1β-receptor interactions.
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