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Mechanisms and inhibitors of apoptosis in cardiovascular diseases

Sylvia S Singh1, Peter M Kang

  • 1Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Current Pharmaceutical Design
|June 3, 2011
PubMed

Insights

Programmed cell death, or apoptosis, is crucial in heart failure. This review covers apoptotic pathways and interventions for heart failure, focusing on chronic stages.

Area of Science:

  • Cardiovascular Biology
  • Cell Death Mechanisms

Background:

  • Apoptosis plays a key role in cardiovascular diseases like myocardial infarction, reperfusion injury, and heart failure.
  • While anti-apoptotic strategies exist for ischemia-reperfusion injury, fewer target the chronic phase of heart failure.

Purpose of the Study:

  • To summarize apoptotic pathways implicated in heart failure.
  • To discuss current anti-apoptotic interventions for heart failure.
  • To review the clinical implications of these interventions.

Main Methods:

  • Literature review of apoptotic pathways in heart failure.
  • Analysis of existing anti-apoptotic interventions.
  • Evaluation of clinical relevance and implications.

Main Results:

  • Several apoptotic pathways are involved in the pathogenesis of heart failure.
  • Various endogenous inhibitors, caspase inhibitors, and PARP-1 inhibitors show anti-apoptotic potential.
  • Limited interventions are currently focused on the chronic stage of heart failure.

Conclusions:

  • Understanding apoptosis is critical for managing heart failure.
  • Targeting specific apoptotic pathways offers therapeutic potential for heart failure.
  • Further research is needed to translate anti-apoptotic strategies into effective chronic heart failure treatments.

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