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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

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Related Experiment Video

Updated: Jun 1, 2026

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

Knowledge translation and guidelines: a transfer, translation or transformation process?

Alison Kitson1

  • 1The University of Adelaide, Discipline of Nursing, School of Population Health and Clinical Practice and Royal Adelaide Hospital, Adelaide, South Australia, Australia.

International Journal of Evidence-Based Healthcare
|June 3, 2011
PubMed
Summary

Guidelines are complex communication tools, not rigid rules. Viewing them flexibly helps practitioners understand successful implementation strategies and challenges in healthcare settings.

Related Experiment Videos

Last Updated: Jun 1, 2026

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

Area of Science:

  • Healthcare implementation science
  • Knowledge management in healthcare

Background:

  • Current approaches to healthcare guidelines often treat them as rigid documents.
  • This perspective limits understanding of successful implementation strategies.

Purpose of the Study:

  • To advocate for conceptualizing guidelines as flexible, interpretative tools.
  • To explore how this perspective enhances understanding of guideline implementation.
  • To propose new conceptualizations for multifaceted implementation interventions.

Main Methods:

  • Formulating theoretical arguments based on evidence of successful guideline implementation.
  • Contrasting research evidence with practitioners' accounts of guideline introduction.
  • Developing new conceptualizations for guideline implementation.

Main Results:

  • Guidelines function as complex communication vehicles, stimulating discussion and learning.
  • Successful implementation requires complex, multifaceted interventions tailored to identified barriers.
  • Research designs should integrate process and causal models, prioritizing process studies.

Conclusions:

  • Rethinking guidelines as flexible, interpretative tools is crucial for effective implementation.
  • Implementation research needs to address conceptual, theoretical, and methodological challenges.
  • Shifting focus from behavior change to knowledge management and diverse organizational theories is recommended.