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Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance
Antonio González-Chávez1, Luis Ernesto Simental-Mendía, Sandra Elizondo-Argueta
1Unidad 308, Servicio de Medicina Interna, Hospital General de México, Secretaría de Salud, México, D. F., Mexico. antglez51@yahoo.com.mx.
Cirugia Y Cirujanos
|June 3, 2011
Summary
In healthy individuals, a high triglyceride/HDL-cholesterol ratio is linked to insulin resistance (IR). This finding suggests the ratio may serve as an early indicator for metabolic dysfunction, even before overt disease develops.
Area of Science:
- Endocrinology
- Metabolic Health
- Cardiovascular Disease Prevention
Background:
- Insulin resistance (IR) is a key factor in cardiovascular disease development.
- IR is linked to hypertension and metabolic syndrome, often indicated by the triglyceride/HDL-cholesterol (TGL/HDL) ratio.
Purpose of the Study:
- To investigate the association between the TGL/HDL ratio and IR in apparently healthy subjects.
- To identify potential early markers for metabolic dysfunction.
Main Methods:
- Cross-sectional study of 177 healthy adults (men and non-pregnant women).
- Comparison of individuals with and without IR, analyzing age, gender, BMI, and waist circumference.
- Exclusion of participants with chronic diseases like diabetes, renal, or hepatic disease.
Main Results:
- An elevated TGL/HDL ratio was found in 61.4% of subjects with IR versus 38.6% without IR.
- The elevated TGL/HDL ratio showed a significant association with the presence of IR (OR 2.64).
Conclusions:
- An elevated TGL/HDL ratio is significantly associated with insulin resistance in apparently healthy individuals.
- The TGL/HDL ratio may serve as a valuable indicator for detecting IR in the general population.
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