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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI)

E Ettorre1, E Cerra, B Marigliano

  • 1Department of Cardiovascular, Respiratory, Nephrological and Geriatric Sciences Sapienza University of Rome, Umberto I, Policlinico di Roma. Viale del Policlinico 155, I-00161 Roma, Italy.

Archives of Gerontology and Geriatrics
|June 3, 2011
PubMed

Insights

Controlling cardiovascular risk factors (CRF) significantly impacts cognitive decline in mild cognitive impairment (MCI). Patients with MCI and CRF progress to Alzheimer

Area of Science:

  • Neurology
  • Geriatrics
  • Public Health

Background:

  • Limited therapeutic options exist for Alzheimer's disease (AD).
  • Evidence suggests controlling vascular risk factors may modify AD progression.
  • Cardiovascular risk factors (CRF) are increasingly recognized as potential contributors to cognitive decline.

Purpose of the Study:

  • To investigate the role of CRF in patients with mild cognitive impairment (MCI).
  • To evaluate the influence of CRF on cognitive and behavioral features in MCI.
  • To assess the impact of CRF on the progression from MCI to dementia.

Main Methods:

  • Study included 50 patients diagnosed with MCI using Petersen's criteria.
  • Patients were assessed for the presence of cardiovascular risk factors (CRF).
  • Cognitive status, behavioral features, and progression to dementia were monitored over time.

Main Results:

  • 60% of MCI patients with CRF progressed to dementia, versus 32% without CRF.
  • MCI patients with CRF exhibited worse cognitive performance.
  • MCI patients with CRF also showed increased behavioral disorders, depression, and functional disability.

Conclusions:

  • Cardiovascular risk factors play a key role in the cognitive decline of MCI patients.
  • MCI patients with CRF have a higher conversion rate to AD.
  • Early management of CRF may be crucial for mitigating cognitive decline in MCI.

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