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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
Published on: August 19, 2016
Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes
Dennis Tappe1, Marco H Schulze, Mark van der Linden
1Institute of Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. dtappe@hygiene.uni-wuerzburg.de
Abstract:
Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries. We here report a case of severe protracted disease after a minor skin infection in a young traveler returning from West Malaysia which was caused by an unusual emm-type strain harboring speG and smeZ superantigen genes.
Insights
Streptococcal toxic shock syndrome (STSS) is a severe illness. A case report details a protracted STSS in a traveler from West Malaysia caused by an unusual *Streptococcus* strain with specific superantigen genes.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Streptococcal toxic shock syndrome (STSS) presents a significant global health challenge.
- Early identification and understanding of causative agents are crucial for effective management.
Observation:
- A young traveler returning from West Malaysia developed a severe and protracted illness.
- The illness followed a seemingly minor skin infection.
Findings:
- The causative agent was identified as an unusual *Streptococcus* strain.
- This strain harbored the *speG* and *smeZ* superantigen genes, contributing to disease severity.
Implications:
- This case highlights the potential for severe STSS from seemingly innocuous skin infections.
- Understanding the genetic makeup of *Streptococcus* strains, particularly superantigen genes, is vital for predicting and treating STSS.
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