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Published on: October 12, 2017

Elevated triglycerides and risk of myocardial infarction in HIV-positive persons

Signe W Worm1, David A Kamara, Peter Reiss

  • 1Copenhagen HIV Programme, University of Copenhagen, Denmark. sww@cphiv.dk

AIDS (London, England)
|June 3, 2011
PubMed

Insights

Elevated triglyceride levels show a small, independent association with myocardial infarction (MI) risk in HIV-positive individuals. This association is reduced after accounting for cholesterol, cardiovascular disease, and HIV-related factors.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Elevated triglyceride levels are common in individuals with HIV.
  • The independent contribution of triglycerides to myocardial infarction (MI) risk in this population is not well-established.

Purpose of the Study:

  • To investigate the independent association between elevated triglyceride levels and MI risk in HIV-positive individuals.
  • To adjust for lipid profiles, cardiovascular disease (CVD) risk factors, and HIV-specific factors.

Main Methods:

  • A cohort study involving 33,308 HIV-positive individuals from 1999 to 2008.
  • Multivariable Poisson regression models were employed to assess MI incidence.
  • Adjustments were made for total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), non-lipid CVD risk factors, and HIV/treatment factors.

Main Results:

  • An unadjusted doubling of triglyceride levels was associated with a 67% increased MI risk.
  • After adjusting for TC and HDL-C, the relative risk (RR) for MI per triglyceride doubling decreased to 1.33.
  • Further adjustments for CVD risk factors and HIV-specific factors attenuated the RR to 1.11 (95% CI 1.01-1.23), indicating a marginally significant independent effect.

Conclusions:

  • Higher triglyceride levels are marginally independently associated with increased MI risk in HIV-positive persons.
  • The independent effect of triglycerides on MI risk in this population appears to be small after accounting for various confounders.
Abstract

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