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Peripheral neuropathy associated with osteosarcoma in a Japanese monkey
H Yasuda1, Y Taniguchi, Y Shigeta
1Third Department of Medicine, Shiga University of Medical Science, Japan.
Jikken Dobutsu. Experimental Animals
|April 1, 1990
Summary
This study reports the first case of dying-back neuropathy in a Japanese monkey linked to osteosarcoma. Nerve fiber loss and demyelination were observed, mirroring human conditions.
Area of Science:
- Veterinary Neurology
- Primate Pathology
- Oncology
Background:
- Osteosarcoma is a primary bone cancer.
- Peripheral neuropathy can be associated with malignancy.
- Macaca fuscata (Japanese monkey) serves as a model organism in biomedical research.
Observation:
- A Japanese monkey (Macaca fuscata) presented with osteosarcoma of the humerus.
- Postmortem examination of lower limb nerves was conducted.
- Morphometric and electron microscopy analyses were performed on nerve tissues.
Findings:
- Significant loss and size reduction of myelinated nerve fibers in the lower limbs.
- Evidence of various demyelinative processes observed via electron microscopy.
- Distal nerve segments showed more pronounced pathological changes than proximal segments, indicating axonal degeneration.
Implications:
- This is the first documented case of malignancy-associated dying-back neuropathy in a monkey.
- The findings suggest that non-human primates can develop peripheral neuropathies similar to those seen in humans with cancer.
- This case highlights the importance of considering paraneoplastic syndromes in veterinary oncology and comparative pathology.