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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Microtubules in Signaling

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...

Catenins

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...

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Related Experiment Video

Updated: Jun 1, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Wnt signalling escapes to cilia.

Rieko Ajima, Hiroshi Hamada

Nature Cell Biology

|June 3, 2011

Summary

This summary is machine-generated.

Jouberin (Jbn) sequesters beta-catenin to the primary cilium, restraining Wnt signaling. This discovery clarifies how primary cilia regulate canonical Wnt responses.

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The Soft Agar Colony Formation Assay

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Last Updated: Jun 1, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

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Published on: December 10, 2021

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Area of Science:

Cell Biology
Molecular Biology
Developmental Biology

Background:

Canonical Wnt signaling is crucial for development and disease.
Primary cilia are increasingly recognized as key regulators of cellular signaling pathways.
The precise mechanisms by which primary cilia modulate Wnt signaling remained largely unknown.

Discussion:

This study identifies Jouberin (Jbn) as a novel modulator of Wnt signaling within the primary cilium.
Jbn directly interacts with beta-catenin, sequestering it within the ciliary compartment.
This sequestration effectively limits the availability of beta-catenin for downstream signaling.

Key Insights:

Jouberin (Jbn) acts as a ciliary anchor for beta-catenin.
Primary cilia restrain Wnt signaling by sequestering key pathway components like beta-catenin.
This mechanism provides a direct link between primary cilia structure and Wnt pathway regulation.

Outlook:

Further investigation into Jbn's role in other ciliary signaling pathways.
Exploring the therapeutic potential of targeting the Jbn-beta-catenin interaction in Wnt-related diseases.
Understanding how Jbn itself is regulated within the primary cilium.