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Updated: Jun 1, 2026
10:22
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Anaphylactic reaction to intravenous diclofenac
Ranju Singh1, Deepak Bansal, Neha Baduni
1Department of Anesthesiology and Critical Care, Lady Hardinge Medical College & Associated Hospitals, New Delhi - 110 001, India.
Summary
Anaphylaxis from intravenous diclofenac sodium is rare but can mimic pulmonary embolism. This case highlights the importance of considering drug reactions in postoperative patients.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID), is frequently used for postoperative pain management to reduce opioid requirements.
- Intravenous administration of diclofenac sodium is common for analgesia.
- Anaphylactic reactions to intravenous diclofenac sodium are exceptionally rare.
Observation:
- A 25-year-old primigravida experienced a severe anaphylactic reaction postoperatively.
- The patient's clinical presentation strongly resembled symptoms of a pulmonary embolism.
- The reaction occurred shortly after the administration of intravenous diclofenac sodium.
Findings:
- The patient suffered a confirmed anaphylactic reaction attributed to intravenous diclofenac sodium.
- The diagnostic challenge was significant due to the overlapping symptoms with pulmonary embolism.
- This case underscores the potential for rare but severe adverse drug reactions.
Implications:
- Clinicians should maintain a high index of suspicion for anaphylaxis in postoperative patients presenting with unexplained symptoms, even when on NSAIDs.
- Awareness of rare drug-induced anaphylaxis is crucial for accurate and timely diagnosis.
- This case emphasizes the need for careful patient monitoring following administration of intravenous diclofenac sodium.
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