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Related Experiment Video

Updated: Jun 1, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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Sleep in Wilson's disease: Questionnaire based study.

Archana B Netto1, Sanjib Sinha, Arun B Taly

  • 1Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, India.

Annals of Indian Academy of Neurology
|June 3, 2011
PubMed
Summary
This summary is machine-generated.

Sleep disturbances are more common in Wilson's disease (WD) patients. Sleep questionnaires effectively identified these abnormalities, aiding in early detection and management of sleep issues in WD.

Keywords:
Epworth sleepiness scalePittsburg sleep quality indexWilson’s diseasesleepsleep questionnaire

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Area of Science:

  • Neurology
  • Sleep Medicine
  • Clinical Research

Background:

  • Wilson's disease (WD) is a genetic disorder affecting copper metabolism.
  • Sleep abnormalities are increasingly recognized in neurological conditions.
  • The impact of WD on sleep quality and daytime sleepiness requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of sleep abnormalities in patients with Wilson's disease.
  • To evaluate the utility of sleep questionnaires in detecting sleep disturbances in WD.
  • To compare sleep quality between WD patients and healthy controls.

Main Methods:

  • A cohort of 25 WD patients and 24 controls underwent phenotypic and MRI evaluation.
  • Participants completed the Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS).
  • Statistical analysis compared questionnaire scores between WD patients and controls.

Main Results:

  • Wilson's disease patients exhibited significantly higher mean PSQI scores (P = 0.03) compared to controls.
  • Abnormal PSQI scores were more frequent in WD patients (15/25) than controls (6/24).
  • Sleep questionnaires detected abnormalities in 16 WD patients versus 8 controls (P = 0.004), indicating a higher prevalence of sleep issues in WD.

Conclusions:

  • Sleep disturbances are significantly more prevalent in individuals with Wilson's disease.
  • Sleep questionnaires are effective tools for identifying sleep abnormalities in WD patients.
  • Further research with larger cohorts is warranted to fully elucidate sleep patterns in WD.