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Related Experiment Videos

Adrenergic and cholinergic interaction in central ventilatory control.

M D Burton1, D C Johnson, H Kazemi

  • 1Medical Services (Pulmonary-Critical Care-Unit), Massachusetts General Hospital, Boston.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 1, 1990
PubMed
Summary
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Adrenergic agents influence cardiorespiratory control, potentially through acetylcholine release and cyclic AMP production. This study investigates the interplay between these mechanisms in dogs, revealing distinct roles in ventilation and circulation.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Respiratory Physiology

Background:

  • The ventrolateral medulla integrates cardiorespiratory control.
  • Cholinergic and adrenergic neurons in the ventrolateral medulla influence ventilation and circulation.
  • The interaction between adrenergic agents, acetylcholine release, and cyclic AMP (cAMP) in cardiorespiratory regulation is not fully understood.

Purpose of the Study:

  • To determine if the cardiorespiratory effects of adrenergic agents are mediated by changes in acetylcholine release.
  • To investigate the role of cAMP production as an intermediate in these pathways.
  • To elucidate the coordinated or independent actions of cholinergic and adrenergic systems in cardiorespiratory control.

Main Methods:

  • Ventriculocisternal perfusion in anesthetized, spontaneously breathing dogs.

Related Experiment Videos

  • Administration of adrenergic agents (isoproterenol, clonidine), beta-antagonist (esmolol), cholinergic antagonist (atropine), and adenylate cyclase activator (forskolin).
  • Measurement of ventilation (VE), heart rate, and cardiac output.

    • Main Results:

    • Isoproterenol (ISO) increased VE, heart rate, and cardiac output; these effects were blocked by esmolol and atropine (for VE).
    • Forskolin increased VE, and its effect was blocked by atropine.
    • Clonidine decreased VE, heart rate, and cardiac output.

    Conclusions:

    • Adrenergic agents modulate cardiorespiratory function through pathways involving both acetylcholine release and cAMP.
    • Cholinergic mechanisms are critical for the ventilatory effects of beta-adrenergic stimulation.
    • Circulatory effects of beta-adrenergic stimulation may be independent of cholinergic pathways.