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ER Retrieval Pathway

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...

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Pattern-based Search of Epigenomic Data Using GeNemo

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Searching NCBI databases using Entrez.

Gretchen Gibney¹, Andreas D Baxevanis¹

¹Bethesda, Maryland.

Current Protocols in Bioinformatics

|June 3, 2011

Summary

This summary is machine-generated.

The National Center for Biotechnology Information (NCBI) Entrez system simplifies biological data retrieval by leveraging natural connections between database entries. This system allows users to find comprehensive information on biological entities efficiently.

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Area of Science:

Bioinformatics
Computational Biology
Database Management

Background:

Biological databases contain numerous interconnected entries.
Accessing information across disparate databases can be inefficient.
The National Center for Biotechnology Information (NCBI) Entrez system was developed to address these challenges.

Purpose of the Study:

To describe the NCBI Entrez system as a unified interface for biological information retrieval.
To illustrate methods for querying and accessing data within Entrez.
To introduce the Cn3D structure visualization tool.

Main Methods:

Utilizing pre-existing biological relationships between database entries.
Employing text-based search protocols for information retrieval.
Leveraging built-in Entrez features for advanced querying.
Discussing a support protocol for saving frequent queries.

Main Results:

Demonstration of basic and alternate search protocols within Entrez.
Illustration of information retrieval for biological entities.
Explanation of how to save frequently used queries.
Introduction to the Cn3D tool for structure visualization.

Conclusions:

The NCBI Entrez system provides an efficient and integrated approach to accessing biological information.
Entrez simplifies data retrieval by exploiting inherent database connections.
Cn3D offers valuable visualization capabilities for biological structures.