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14:15
A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
[T lymphocyte function in laryngectomized patients]
Milovan V Dimitrijević1, Zoran R Dudvarski, Slavko S Vucićevic
1Klinika za otorinolaringologiju i maksilofacijalnu hirurgiju, KCS Univerzitet u Beogradu, Medicinski fakultet, Beograd, Srbija.
Acta Chirurgica Iugoslavica
|June 4, 2011
Summary
Patients with laryngeal cancer exhibit significant immune dysfunction, particularly in T lymphocyte function. This immune deficiency, specifically reduced T lymphocyte mitotic activity, correlates with the presence of malignant tumors.
Area of Science:
- Immunology
- Oncology
Context:
- Laryngeal cancer represents a significant portion of head and neck malignancies.
- Understanding immune competence in cancer patients is crucial for prognosis.
- Limited research exists on immune disorders in laryngeal cancer patients.
Purpose:
- To assess general immunocompetence in laryngeal cancer patients.
- To identify and quantify immune disorders.
- To explore the association between immune status and malignant tumors.
Summary:
- Forty-two patients with squamous cell laryngeal cancer were studied.
- Immune competence was evaluated pre-operatively and nine months post-operatively.
- Key markers assessed included T lymphocyte function, monocyte levels, and mononuclear phagocyte activity.
Impact:
- Preoperative assessment revealed decreased T lymphocyte proliferative response to PHA.
- Monocyte counts and mononuclear phagocyte activity remained elevated.
- Immune disorders, especially T lymphocyte dysfunction, are linked to laryngeal carcinoma presence.
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