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Updated: Jun 1, 2026
Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
Age-associated development of inflammation in Wistar rats: Effects of caloric restriction
Daniel Horrillo1, Johanna Sierra, Carmen Arribas
1Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, 28922, Madrid, Spain.
Context:
Insulin resistance and type 2 Diabetes have been associated to a low grade of inflammation and their prevalence increase with ageing.
Objective:
To analyse the development of inflammation in adipose tissue, liver, muscle and hypothalamus during ageing and the effects of caloric restriction.
Materials And Methods:
We have analysed the expression of inflammatory cytokines (TNFα, IL1-β, IL-12B and IL-6), proteins involved in macrophage recruitment (MCP-1, CCR2), TLR4 and macrophage markers (CD11c, CD11b and arginase1). Immunohistochemistry of macrophages has also been performed.
Results:
All studied tissues present signs of inflammation during ageing, but with different pattern and intensity. Caloric restriction decreases the expression of most of inflammatory markers.
Discussion And Conclusions:
These data indicate a role of adiposity in the development of inflammation and insulin resistance during ageing. Dietetic intervention could be a useful tool to ameliorate the development of inflammation and insulin resistance associated with ageing.
