Maternal caffeine consumption and sine causa recurrent miscarriage

Area of Science:

• Reproductive Medicine
• Perinatal Health
• Obstetrics

Background:

• Recurrent miscarriage (RM) affects a significant number of women.
• The etiology of RM, particularly sine causa RM, remains incompletely understood.
• Periconceptional and early gestational lifestyle factors require further investigation.

Purpose of the Study:

• To investigate the association between caffeine consumption and sine causa recurrent miscarriage (SC-RM).
• To determine if caffeine intake during the periconceptional period and early gestation influences SC-RM risk.
• To control for potential confounding factors, including pregnancy-related symptoms.

Main Methods:

• A retrospective case-control study design was employed.
• The study included 52 women with SC-RM and 260 healthy pregnant controls.
• Data analysis utilized SPSS 17 for Windows.

Main Results:

• Women with SC-RM reported higher caffeine consumption than controls.
• Each 100mg/day increase in caffeine intake was associated with a 2.724-fold increased odds of SC-RM (p<0.001).
• This association persisted after adjusting for confounding covariates.

Conclusions:

• Caffeine intake during the periconceptional period and early gestation appears to elevate the risk of SC-RM.
• The observed risk is independent of pregnancy-related symptoms and covariates like age and tobacco use.
• Limiting caffeine consumption may be a potential preventive strategy for women at risk of recurrent miscarriage.