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Variation in intracellular P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) in virus-infected cells
D J Johnston1, C A Hart, A G McLennan
1Department of Biochemistry, University of Liverpool, U.K.
The Biochemical Journal
|June 15, 1990
Abstract:
The effect of virus infection on the intracellular concentration of the proposed stress alarmone P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) has been examined in Vero cells. Compared with exposure to 0.8 mM-Cd2+, which causes a 30-fold increase in Ap4A, infection with simian virus 40 and poliovirus causes only a 2-fold increase, whereas herpes simplex virus type 1 results in a decrease in Ap4A during the course of the infection.