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Infliximab-related seizures: a first case study

Francesco Brigo1, Luigi Giuseppe Bongiovanni, Roberto Cerini

  • 1Department of Neurological, University of Verona, Verona, Italy. dr.francescobrigo@gmail.com

Epileptic Disorders : International Epilepsy Journal with Videotape
|June 4, 2011
PubMed

Insights

Seizures are a rare side effect of infliximab treatment. This case report details EEG and MRI findings in a patient experiencing infliximab-related seizures, highlighting potential drug-induced encephalopathy.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Immunology

Background:

  • Infliximab (a TNF-alpha inhibitor) is used to treat inflammatory conditions.
  • Seizures are an exceptionally rare adverse effect of infliximab therapy.
  • Detailed electroencephalogram (EEG) and neuroimaging findings in infliximab-related seizures are not well-documented.

Observation:

  • A patient developed acute-onset seizures temporally associated with infliximab administration.
  • Cerebral magnetic resonance imaging (MRI) revealed encephalopathy predominantly affecting cortical regions.
  • Electroencephalography (EEG) demonstrated focal paroxysmal activity.

Findings:

  • Seizures and EEG abnormalities resolved completely within days of infliximab withdrawal.
  • No alternative causes for the seizures were identified.
  • The temporal relationship and clinical response strongly suggest infliximab-induced seizures, potentially secondary to encephalopathy.

Implications:

  • This case highlights a potential link between infliximab therapy and seizures, possibly mediated by drug-induced encephalopathy.
  • Further research is needed to determine if infliximab itself is epileptogenic or if seizures result from associated encephalopathy.
  • Clinicians should consider infliximab-induced seizures in patients presenting with new-onset seizures during treatment.

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