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Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Cancer interception.

Elizabeth H Blackburn¹

¹Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA. Elizabeth.Blackburn@ucsf.edu

Cancer Prevention Research (Philadelphia, Pa.)

|June 4, 2011

Summary

This summary is machine-generated.

Cancer risk can be reduced through active, pharmacologic approaches, not just passive avoidance. Cancer interception targets early stages, offering new ways to combat cancer development.

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Area of Science:

Oncology
Cancer Biology
Pharmacology

Background:

Traditional cancer risk reduction focuses on passive methods like smoking cessation.
Advances in cancer biology and treatment necessitate exploring active, pharmacologic strategies for risk reduction.
Most new lung cancers occur in former or current smokers, highlighting limitations of passive avoidance.

Purpose of the Study:

To advocate for active, pharmacologic cancer risk reduction strategies.
To introduce and define 'cancer interception' as an active approach to combatting cancer.
To emphasize the potential of risk-reducing agents, analogous to cardiovascular disease management.

Main Methods:

Review of recent advances in cancer biology and treatment modalities.
Examination of specific examples like hedgehog pathway inhibitors and lenalidomide.
Discussion of molecular techniques, including next-generation sequencing, applied to premalignancy.

Main Results:

Hedgehog pathway inhibitors show efficacy in intercepting basal cell neoplasia in Gorlin syndrome.
Lenalidomide effectively intercepts the progression of high-risk smoldering multiple myeloma.
Growing knowledge of cancer biology, including telomere maintenance, reveals new interception avenues.

Conclusions:

Cancer interception, an active approach, is timely due to advances in cancer biology.
Pharmacologic agents can intercept cancer development at early stages, similar to managing chronic diseases.
Public and medical community education is crucial for the acceptance of cancer interception strategies.