Nephrogenic systemic fibrosis: a case report and review of the literature
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Updated: Jun 1, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Sam V Truong1, Jennifer K Chen, Amy Reinstadler
1Department of Dermatology, University of California-Irvine, CA 92697, USA. struong@uci.edu
Abstract:
The authors report a case of a patient who presented with thick, indurated, hyperpigmented plaques of the bilateral upper and lower extremities, ultimately discovered to be attributed to nephrogenic systemic fibrosis. The case was written to highlight the clinical manifestations of nephrogenic systemic fibrosis, as well as to make dermatologists aware of this disease, their role in diagnosis and management, and review treatment options.
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