Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Generalized lichen nitidus-like eruption following dupilumab initiation.

JAAD case reports·2026

Same author

Evaluation of multimodal large language models for psoriasis diagnosis, severity grading, and treatment recommendations from clinical photographs: ChatGPT shows superior performance compared to other large language models.

Frontiers in medicine·2026

Same author

Flagellate hyperpigmentation.

The British journal of dermatology·2026

Same author

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Being a Target for Glycation by Methylglyoxal Contributes to Therapeutic Efficacy of Injectable Collagen Hydrogels Post-Myocardial Infarction.

Gels (Basel, Switzerland)·2026

Same author

Hydroxychloroquine in the treatment of lichen planus-like cutaneous immune-related adverse events.

JAAD case reports·2026

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

Mesenchymal stem cells for cardiovascular regeneration.

Drew Kuraitis¹, Marc Ruel, Erik J Suuronen

¹Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.

Cardiovascular Drugs and Therapy

|June 4, 2011

Summary

Mesenchymal stem cells (MSCs) show potential for cardiovascular regeneration after heart attack, but clinical application faces challenges. Further research is needed to confirm their effectiveness and integration into heart tissue.

More Related Videos

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Related Experiment Videos

Last Updated: Jun 1, 2026

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Area of Science:

Regenerative Medicine
Cardiovascular Biology
Stem Cell Therapy

Background:

The heart possesses limited intrinsic self-repair mechanisms post-myocardial infarction.
Mesenchymal stem cells (MSCs) are explored for regenerating mesenchyme-derived tissues.
MSCs show promise in vitro for cardiomyogenic and vasculogenic differentiation.

Purpose of the Study:

To review the evidence for using MSCs in cardiovascular regeneration.
To evaluate the potential of MSCs for repairing heart tissue after injury.
To identify limitations hindering the clinical use of MSCs for cardiac repair.

Main Methods:

Review of in vitro and in vivo studies on MSCs for cardiovascular regeneration.
Analysis of evidence for MSC differentiation into cardiac and vascular lineages.
Examination of proposed mechanisms of MSC action, including paracrine effects and direct differentiation.

Main Results:

In vitro studies suggest MSCs can differentiate into cardiomyocytes and vascular cells.
In vivo, MSCs may promote vascularization and cardiomyocyte protection via paracrine signaling.
Definitive proof of MSC cardiomyocytic differentiation and functional integration in vivo is lacking.

Conclusions:

MSCs represent a potential cell source for cardiovascular regeneration.
Paracrine mechanisms are likely key to MSCs' beneficial effects in the myocardium.
Further investigation is required to overcome limitations and enable clinical translation of MSC-based cardiac therapies.