Related Experiment Video
Updated: Jun 1, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
A new cytotoxic β-carboline alkaloid from Galianthe thalictroides
Patrícia O Figueiredo1, Fernanda R Garcez, Maria de Fátima C Matos
1Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Abstract:
A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H- β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.
Related Concept Videos
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules

