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Updated: Jun 1, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Expression of P-selectin, von Willebrand and endothelin-1 after carotid artery stenting
1Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, PR China.
Insights
Carotid artery stenting (CAS) increases plasma levels of P-selectin, von Willebrand factor (vWF), and endothelin-1. Higher vWF levels post-CAS may indicate increased restenosis risk.
Area of Science:
- Vascular Biology
- Cardiovascular Interventions
- Biomarker Research
Background:
- Carotid artery stenting (CAS) is a procedure to open blocked carotid arteries.
- Understanding the molecular changes post-CAS is crucial for patient outcomes.
Purpose of the Study:
- To investigate the impact of CAS on plasma levels of P-selectin, von Willebrand factor (vWF), and endothelin-1.
- To assess the relationship between these biomarkers and procedural complexity or restenosis.
Main Methods:
- Plasma levels of P-selectin, vWF, and endothelin-1 were measured in 67 patients before and at multiple time points after CAS.
- Patients were stratified into groups based on lesion complexity (simple vs. complex).
Main Results:
- CAS significantly increased plasma levels of P-selectin, vWF, and endothelin-1 immediately post-procedure.
- Higher vWF and endothelin-1 levels were observed in patients with complex lesions (two stents).
- Elevated 24-hour vWF levels were associated with restenosis within one year.
Conclusions:
- CAS induces a significant increase in plasma P-selectin, vWF, and endothelin-1, reflecting endothelial injury.
- Post-CAS vWF levels may serve as an early indicator for restenosis risk.
- Further research is needed to confirm the association between these biomarkers and long-term restenosis after CAS.
Background:
This study was designed to investigate the impact of carotid artery stenting (CAS) on plasma levels of P-selectin, von Willebrand (vWF) and endothelin-1.
Patients And Methods:
Sixty-seven patients who received CAS were divided into group 1 (one stent for a simple lesion, n = 38) and group 2 (two stents for complex lesions, n = 29). The levels of P-selectin, vWF and endothelin-1 were measured before CAS, 1 h, 6h, 24 h and 2 weeks after the stenting.
Results:
Sixty-one patients completed one-year follow up. Restenosis was noted in 14 (23 %) patients, among these three (4.8 %) had a restenosis of > 50 % of the vascular lumen. In all patients, the levels of P-selectin, vWF and endothelin-1 increased immediately after CAS (P < 0.05 or < 0.01). The levels of vWF and endothelin-1 in group 2 were higher than in group 1 (P < 0.05 or 0.01). There was no significant difference in P-selectin and endothelin-1 between the restenosis and non-restenosis group (P > 0.05). The 24 h vWF in patients with restenosis were higher than in non-restenosis group (P < 0.05).
Conclusions:
CAS results in a significant increase in plasma P-selectin, vWF and endothelin-1. The post-CAS levels of P-selectin, vWF and endothelin-1 are related to the extent of endothelial injury. Whether they are associated with restenosis 12 months after the treatment requires further investigation.
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